IPv6 unicast addresses of all types (excluding the unspecified address) can be assigned to node interfaces. The loopback address can be assigned only to the loopback interface of a node.

All physical interfaces (excluding VIPA and loopback) are required to have at least one link-local unicast address. z/OS® Communications Server allows only a single link-local address per interface. Other platforms might have more than one. A single interface can be assigned multiple unicast or anycast IPv6 addresses. Multiple IPv6 multicast groups of any scope can be joined on a single interface. A unicast address or a set of unicast addresses might be assigned to multiple physical interfaces if the implementation treats the multiple physical interfaces as one interface when presenting it to the Internet layer.

Currently, IPv6 continues the IPv4 model that a subnet prefix is associated with one link. Multiple subnet prefixes can be assigned to the same link.