Multicultural support gives countries the option of translating commands and keywords so that users can enter them in the country's national language. In addition, panels, messages, and literal modules are provided with the product. The supported languages are German, Swiss-German, and Japanese.

When multicultural support is enabled, users can be required to enter certain keywords in the national language and not in English.

When the Danish, French, Korean, Traditional Chinese, Simplified Chinese, Spanish, Brazilian-Portuguese, or Italian session language is specified, its respective literal module is used. However, the ISPF product panels and messages are displayed in English.