The Function keys pull-down has two choices that are equivalent to the KEYLIST ON and KEYLIST OFF commands:

Enable keylists

Causes ISPF to use the keylist defined with the panel (equivalent to the KEYLIST ON command). Enable keylists is the default. It is unavailable if it is the current setting.

Disable keylists

Causes ISPF to ignore the keylist defined with the panel (equivalent to KEYLIST OFF). It is unavailable if it is the current setting.