You have configured your client channel to use the client channel definition table(CCDT) with Secure Socket Layer(SSL) enabled.
Using the amqsputc sample program to connect to your queue manager results in the following:
The key database modifications are not recognized by the queue manager. Whenever changes are made to the certificates in the SSL key database of a WebSphere MQ server (after the SSL channel has been started), then the WMQ security information must be refreshed in order for the changes to be recognized.
Resolving the problem
Recycle the queue manager to pick up the SSL configuration changes.
MQ V6.0 / V7.x
Recycle the queue manager or use following runmqsc command to refresh SSL:
Refresh Security type(ssl)
Note: A "modification" of the key database constitutes any additions, or deletions of certificates within the key database, regardless of type (Signer Certificates, Intermediate Certificates, Personal Certificates, and so on.).